gsk-3 inhibitor 5 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T77554	GSK-3 Inhibitor 5	4-Cyanophenacyl bromide	GSK-3
	GSK-3 Inhibitor 5 (4-Cyanophenacyl bromide) is a ketone derivative that is used as an intermediate in pharmaceuticals and organic synthesis, and inhibits glycogen synthase kinase 3 (GSK-3).		GSK-3
T8605	GS87	4-[5-[[(3-Phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridine	GSK-3
	GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.		GSK-3
T7361	Verucerfont	NBI77860,GSK561679	CRFR
	Verucerfont (NBI77860) is an antagonist of corticotropin-releasing factor receptor 1 (CRF1) .		CRFR
T2277	Losmapimod	GSK-AHAB,GW856553X,GW856553,SB856553	p38 MAPK , Autophagy
	Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).		p38 MAPK , Autophagy
T2240	GSK2578215A		Mitophagy , LRRK2 , Autophagy
	GSK2578215A is a potent and selective LRRK2 kinase inhibitor.		Mitophagy , LRRK2 , Autophagy
T10172	5-Iodo-indirubin-3'-monoxime		GSK-3 , CDK
	5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s: 9, 20 and 25 nM).		GSK-3 , CDK
T7473	5-Bromoindole		GSK-3
	5-bromoindole is a potential inhibitor of glycogen synthase kinase 3 (GSK-3)and an important pharmaceutical chemical intermediate		GSK-3
T1917	GSK 3 Inhibitor IX	BIO,GSK 3 IX,6-BIO,6-Bromoindirubin-3'-oxime,MLS 2052,6-bromoindirubin-3-oxime	Apoptosis , GSK-3 , Tyrosine Kinases , CDK
	GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex. It inhibits (GSK-3α/β)/CDK1/CDK5 activity with IC50 values of 5 nM/320 nM/83 nM, respectively.		Apoptosis , GSK-3 , Tyrosine Kinases , CDK
T3067	Tideglusib	NP-12,NP031112	GSK-3
	Tideglusib (NP031112), a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities.		GSK-3
T1957	AZD2858		GSK-3
	AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.		GSK-3
T2378	RGB-286638 free base		GSK-3 , MEK , JAK , CDK
	RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 a...		GSK-3 , MEK , JAK , CDK
T11652	Indirubin-3'-monoxime-5-sulphonic acid		Others
	Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of GSK-3β, CDK5, and CDK1 with IC50s of 80nM,5 nM, and 7 nM, respectively.		Others
T73196	RGB-286638
	RGB-286638 is a multi-target CDK inhibitor that effectively hampers the kinase activity of a range of cyclin-CDK complexes, including cyclin T1-CDK9 (IC50 = 1 nM), cyclin B1-CDK1 (IC50 = 2 nM), cyclin E-CDK2 (IC50 = 3 nM...